Rogue's powers go crazy as she begins to manifest aspects of all of the people she has absorbed over the years; Bishop gets a hard lesson in the Danger Room; Mystique makes her final move to eliminate presidential candidate Robert Kelly and the X-Men race off to stop her.
In an art error, Domino is drawn as a blond Caucasian man here.
A long-running error in the series' indicia begins with this issue; although most of Marvel's titles are dated two months ahead of their publication date, Uncanny slips backward a month. Although this issue was published in Nov. '00, and should be dated January '01, its indicia repeats last issue's month of December '00. This "lost month" error continues until Uncanny #405 in '02.