Peter Parker, class wallflower, has few friends. He lives with his Aunt May and Uncle Ben, as his birth parents died in a plane crash, and only seems to get along with Mary Jane Watson and Harry Osborn. Flash Thompson and Kong Harlan perpetually bully him. On a school fieldtrip to Oscorp Labs, a facility owned and operated by Harry's father Norman, Peter is bit by a very unusual spider. It has affected his physiology in ways Peter is trying to understand. Unfortunately, Norman is well aware of the incident, and is also paying very close attention.