Opening chapter of a two-part story. After ESU President Dwyer announces the closing of the college's night school because of budget woes, minority students protest. Professor Vasquez fuels the protests by demanding the school raise the needed funds by selling the valuable Erskine Manuscripts. Peter Parker visits the university library and discovers the White Tiger stealing the Erskine Manuscript while also fending off an attack by members of a group called The Black Hand. To learn more about the White Tiger, Spidey sneaks into the Daily Globe office and reviews its files, which through flashbacks brings color comic readers up to date on a character who previously had only appeared in the black-and-white magazine DEADLY HANDS OF KUNG FU. Spidey also taps Harlem detective "Black Byrd" for further information on the White Tiger. Spidey wonders if the White Tiger is friend or foe.
This issue's title is taken from William Blake's 1794 poem "The Tyger," the first stanza of which reads: "Tyger! Tyger! burning bright / In the forests of the night / What immortal hand or eye / Could frame thy fearful symmetry?"