The Ghostbusters are back in business and in full swing taking care of ghosts left and right, which keeps them from further investigating the river of slime. Meanwhile, Dana has an uneasy feeling working at the Museum lately, unknown to her that her boss, Janosz, had been possessed by the evil spirit of Prince Vigo living inside a painting. And to add to her troubles, while attempting to give Oscar a bath, both he and Dana are attacked by their slime filled bathtub!
On the cover, the characters have nametags like their movie counterparts. This is the only time Real Ghostbusters characters have had nametags on their uniforms outside of the episode "Elementary My Dear Winston."