Born Mary Louise Alexander, "Weezie" married college sweetheart Jeff Jones in 1966. The two moved to New York in 1967.
Louise made her first appearance in comics as a model for Berni Wrightson’s cover of House of Secrets #92 (also the first appearance of the Swamp Thing). She started working in the industry three years later (1974) as an editor at Warren Comics. She joined Marvel in 1980 as an editor but moved to writing in 1983 for both Marvel and DC.